^*Indicates author to whom correspondence should be addressed

Data requirements for protein identification using chemically-assisted fragmentation and tandem mass spectrometry

Kenton D. Juhlin, Dionne D. Swift, Martin P. Lacey, Paul E. Correa and Thomas W. Keough
The Procter & Gamble Company, PO Box 538707, Cincinnati, OH 45253-8707, USA

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DOI: 10.1255/ejms.758

Chemically-assisted fragmentation combined with multi-dimensional liquid chromatography and matrix-assisted laser desorption/ionization post source decay, matrix-assisted laser desorption/ionization tandem time-of flight or matrix-assisted laser desorption/ionization tandem mass spectrometry for improved sequencing of tryptic peptides

John Flensburg,^a* Anders Tangen,^a Maria Prieto,^b Ulf Hellman^c and Henrik Wadensten^a
aAmersham Biosciences AB, GE Healthcare, Björkgatan 30, SE-751 84 Uppsala, Sweden. E-mail: john.flensburg@ge.com
^bThermo Electron Corporation, 355 River Oaks Parkway, San Jose, CA 95134, USA
^cLudwig Institute for Cancer Research, Box 595, SE-751 24 Uppsala, Sweden

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DOI: 10.1255/ejms.734

A tandem time-of-flight mass spectrometer: combination of a multi-turn time-of-flight and a quadratic-field mirror

Michisato Toyoda,^a Anastassios E. Giannakopulos,^b,* Alex W. Colburn^b and Peter J. Derrick^b
aDepartment of Physics, Graduate School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka 560-0043, Japan
^vbInstitute of Mass Spectrometry and Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK

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DOI: 10.1255/ejms.735

Advantages and drawbacks of popular supercritical fluid chromatography interfacing approaches—a user’s perspective

J. David Pinkston
Procter & Gamble Pharmaceuticals, Health Care Research Center, 8700 Mason-Montgomery Rd, PO Box 8006, Mason, OH 45040, USA. E-mail: pinkston.jd@pg.com

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DOI: 10.1255/ejms.731

On-line solid phase extraction using the Prospekt-2 coupled with a liquid chromatography/tandem mass spectrometer for the determination of dextromethorphan, dextrorphan and guaifenesin in human plasma

Debbie L. Kuhlenbeck,^a Thomas H. Eichhold,^b Steven H. Hoke, II,^b Timothy R. Baker,^a Robert Mensen^c and Kenneth R. Wehmeyer^a,*
aProcter & Gamble Pharmaceuticals, Health Care Research Center, 8700 Mason-Montgomery Rd, Mason, OH 45040-8006, USA. E-mail: wehmeyer.kr@pg.com
^bThe Procter & Gamble Company, Health Care Research Center, 8700 Mason-Montgomery Rd, Mason, OH 45040-8006, USA
^cSpark Holland Inc., 666 Plainsboro Rd, Plainsboro, NJ 08536, USA

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DOI: 10.1255/ejms.737

Development of an ion-pair reverse-phase liquid chromatographic/tandem mass spectrometry method for the determination of an 18-mer phosphorothioate oligonucleotide in mouse liver tissue

Anthony T. Murphy,^a* Patricia Brown-Augsburger,^a Rosie Z. Yu,^b Richard S. Geary,^b Stefan Thibodeaux^a and Bradley L. Ackermann^a
aLilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285, USA. E-mail: atm@lilly.com
^bISIS Pharmaceuticals, Carlsbad, CA 92009, USA

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DOI: 10.1255/ejms.674

Elucidation of tautomer structures of 2-acetyltetrahydropyridine using gas chromatography/mass spectrometry and gas chromatography/infrared spectroscopy

Robert A. Sanders,^a David V. Zyzak,^a Thomas R. Morsch^a and George P. Rizzi^b
aThe Procter & Gamble Company, Winton Hill Business Center, 6300 Center Hill Avenue, Cincinnati, OH 45224, USA
^b2542 Blossomhill Lane, Cincinnati, OH 45224, USA

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DOI: 10.1255/ejms.703

Shotgun sequencing small oligonucleotides by nozzle-skimmer dissociation and electrospray ionization mass spectrometry

Zhaojing Meng and Patrick A. Limbach^*
Rieveschl Laboratories for Mass Spectrometry, Department of Chemistry, PO Box 210172, University of Cincinnati, Cincinnati, OH 45221, USA. E-mail Pat.Limbach@uc.edu

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DOI: 10.1255/ejms.736

Chiral and isomeric analysis by electrospray ionization and sonic spray ionization using the fixed-ligand kinetic method

Lianming Wu^a and R. Graham Cooks^*
Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA. E-mail: cooks@purdue.edu

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DOI: 10.1255/ejms.749

Tandem mass spectrometry characteristics of polyester anions and cations formed by electrospray ionization

Mark A. Arnould,^a,c Rafael Vargas,^b Rita W. Buehner^b and Chrys Wesdemiotis^a,*
a Department of Chemistry, The University of Akron, Akron, Ohio, 44325-3601, USA. E-mail: wesdemiotis@uakron.edu
^b UCB Chemicals Corporation, 2000 Lake Park Drive, Smyrna, Georgia, 30080, USA

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DOI: 10.1255/ejms.746

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