The gas-phase basicities of matrix-assisted laser desorption/ionization matrices

Eur. J. Mass Spectrom. 3, 339–346 (1997)
DOI: 10.1255/ejms.165

The gas-phase basicities of matrix-assisted laser desorption/ionization matrices

R.J.J.M. Steenvoorden, K. Breuker and R. Zenobi^*
Department of Chemistry, Swiss Federal Institute of Technology (ETH), Universitätstrasse 16, CH-8092 Zürich, Switzerland.

ABSTRACT:

The gas-phase basicities of three common matrices used in matrix-assisted laser desorption/ionization (MALDI) have been investigated using laser desorption with Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry. In bracketing type experiments, laser-desorbed ions from 2,5-dihydroxy-benzoic acid, a-cyano-4-hydroxy-cinnamic acid and sinapic acid were tested for their ability to protonate test substances. This study was not limited to protonated matrix species but also included prominent fragments.

Keywords: MALDI, FT-ICR, proton affinity, fragmentation, matrix

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