Fast-atom bombardment mass spectrometry of netilmicin and its 6'-N-aminoacyl derivatives

Eur. J. Mass Spectrom. 4, 265–268 (1998)
DOI: 10.1255/ejms.219

Fast-atom bombardment mass spectrometry of netilmicin and its 6′-N-aminoacyl derivatives

S.I. Kotretsou and V. Constantinou-Kokotou^*
Chemistry Laboratory, Agricultural University of Athens, Iera Odos 75, Athens 11855, Greece.

ABSTRACT:

Mass spectrometric studies on the fragmentation of the clinically used antibiotic netilmicin and its 6′-N-aminoacyl derivatives are reported. Glycosyl cleavage at the C-4 and C-6 positions of the 2- deoxystreptamine unit (2-DOS) forms the main ions.

Keywords: Netilmicin, 6′-N aminoacyl derivatives, FAB, aminocyclitol antibiotics, aminoglycosides.

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