|
Vladimir G. Zaikin
Topchiev
Institute of Petrochemical Synthesis, Russian Academy of Sciences, Leninsky
prospect 29, 119991Moscow, Russia. E-mail: zaikin@ips.ac.ru
John M.
Halket
Drug Control Centre, King’s College London, Franklin-Wilkins
Building, Stamford Street, London SE1 9NN, UK. E-mail:
john.halket@kcl.ac.uk |
| This is the first of
two reviews devoted to derivatization approaches for
“Soft”-ionization mass spectrometry (FAB, MALDI, ESI, APCI) and
deals, in particular, with small molecules. The principles of the main
“Soft”-ionization mass spectrometric methods as well as the reasons
for derivatizing small molecules are briefly described. Derivatization methods
for modification of amines, carboxylic acids, amino acids, alcohols, carbonyl
compounds, monosaccharides, thiols, unsaturated and aromatic compounds etc. to
improve their ionizability and to enhance structure information content are
discussed. The use of “gixed”-charge bearing derivatization reagents
is especially emphasized. Chemical aspects of derivatization and
“Soft”-ionization mass spectrometric properties of derivatives are
considered. |
|
Keywords: APCI-MS, ESI-MS,
MALDI-TOF-MS, FAB-MS, tandem mass spectrometry, post-source decay, chiral, CID,
alcohols, amines, amino acids, aromatic compounds, carboxylic acids, carbonyl
compounds, monosaccharides, thiols, unsaturated compounds |
