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John M. HalketDrug Control Centre, King’s College London,
Franklin-Wilkins Building, Stamford Street, London SE1 9NN, UK. E-mail: john.halket@kcl.ac.uk
Vladimir G. Zaikin
Topchiev Institute of Petrochemical Synthesis,
Russian Academy of Sciences, Moscow, Russia. E-mail: zaikin@ips.ac.ru |
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This is the first of a series of reviews on the application of derivatization in mass spectrometry. A
description is given of advances in silylation as a powerful tool used for increasing the volatility, thermal and thermo-catalytic stability, and chromatographic mobility of polar and
unstable organic compounds. In addition to chemical aspects of silylation, mass spectral properties of silyl derivatives useful for structure determination and quantitation of various
organic and biologically-active compounds, mainly by GC/MS, are described. Practically all tested and widely used silylating agents are described. The role of comprehensive
libraries containing reference mass spectra for various silyl derivatives and search systems in structure determination is emphasized. Applications of silylation for particular
analyses are summarised. |
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Keywords:
Silylation, silyl derivatives, silyl agents, mass spectrometry, electron ionization, chemical ionization, gas chromatography/mass spectrometry, alcohols,
phenols, carboxylic acids, oximes, phosphorous acids, thiols, amines, amides, steroids, amino acids, doping control, urine analysis |
