An overview of some recent developments in ionization methods for mass spectrometry

Eur. J. Mass Spectrom. 9, 539–562 (2003)
DOI: 10.1255/ejms.586

An overview of some recent developments in ionization methods for mass spectrometry

Gary J. Van Berkel
Organic and Biological Mass Spectrometry Group, Chemical Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831-6131, USA. E-mail: vanberkelgj@ornl.gov

ABSTRACT:

An overview of some recent advances in ionization sources for mass spectrometry is presented. Limitations were set so that the overview covers ionization techniques relevant to organic and biological analysis that have appeared in the literature since the year 2000. No effort is made to be comprehensive. Rather, a broad sweep overview of author- subjective highlights among a wide variety of sources is presented. These ionization sources include electron ionization, chemical ionization, various atmospheric plasma ionization sources, laser desorption sources, sonic spray and electrospray ionization sources.

Keywords: overview, ionization, mass spectrometry, EI, CI, APCI, APPI, MALDI, ES

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