High resolution electrospray and electrospray tandem mass spectra of rotenone and its isoxazoline cycloadducts

Eur. J. Mass Spectrom. 10, 691–697 (2004)
DOI: 10.1255/ejms.664

High resolution electrospray and electrospray tandem mass spectra of rotenone and its isoxazoline cycloadducts

Massimiliano Cordaro,^a Leonardo Di Donna,^b Giovanni Grassi,^a Loredana Maiuolo,^b Fabio Mazzotti,^b,c, Enzo Perri,^c Giovanni Sindona^b and Antonio Tagarelli^b
^aDipartimento di Chimica Organica e Biologica, Università, Vill. S. Agata, I-98166 Messina, Italy
^bDipartimento di Chimica, Università della Calabria, cubo 12/C I- 87030 Arcavacata di Rende (CS), Italy
^cIstituto Sperimentale per l’Olivicoltura, Contrada Li Rocchi, I-87036 Rende (CS), Italy

ABSTRACT:

An evaluation of the gas-phase ion chemistry of rotenone (1) by electrospray ionisation (ESI) mass spectrometry (MS) and tandem mass spectrometry (MS²) is presented, aiming at providing tools for its determination in natural and biological matrices. The behaviour of its cycloadducts with benzonitrile-N-oxide (2) and 2,4,6-trimethylbenzonitrile-N-oxide (3) was also evaluated and the MS data thus obtained have provided evidence into the mechanism of formation of the key product ion at m/z 192 which can be considered a marker in the MS and MS² spectra of rotenone and its derivatives

Keywords: Rotenone cycloadducts; High resolution ESI-MS² of rotenone; High-resolution MS²of rotenone cycloadducts

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