Electrospray ionization tandem mass spectrometry determined regioisomeric structures of disubstituted β-cyclodextrin derivatives

Eur. J. Mass Spectrom. 12, 37–42 (2006)
DOI: 10.1255/ejms.793

Electrospray ionization tandem mass spectrometry determined regioisomeric structures of disubstituted β-cyclodextrin derivatives

Hatsuo Yamamura,^a,* Toshifumi Iwata,^a Masao Kawai^a and Akihiro Sato^b
^aGraduate School of Engineering, Gokiso-cho, Showa-ku, Nagoya, Aichi 466-8555, Japan
^bJasco International Co., Ltd, 11-10 Myojin-cho 1-chome Hachioji, Tokyo 192-0046, Japan

ABSTRACT:

Electrospray ionization tandem mass spectrometry was applied to the analysis of regiospecifically disubstituted β-cyclodextrins. Each disubstituted regioisomer showed unique fragmentation, distinguishing each of them unambiguously. These results demonstrate that mass spectrometry is the most straightforward method among those reported in the assignment of regioisomeric structures of these oligosaccharides.

Keywords: electrospray ionization, tandem mass spectrometry, cyclodextrin, regioisomer

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