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Eur. J. Mass Spectrom. 4, 233 - 237 (1998)

Electrospray mass spectrometry analysis of liquid-phase organic synthesis

F. Nativel, C. Enjalbal, F. Lamaty, R. Lazaro, J. Martinez and J.-L. Aubagnac*
UMR 5810, Laboratoire des Aminoacides, Peptides et Protéines, Université Montpellier 2, Place E. Bataillon, 34095 Montpellier Cedex 05, France.

ABSTRACT:
Electrospray ionization mass spectrometry was found to be a valuable tool to follow multi-step organic liquid-phase syntheses. Such an analytical method is not limited to the monitoring of peptide synthesis but could be extended to any supported organic structures, in particular in the field of combinatorial chemistry.

Keywords: Electrospray ionization mass spectrometry, supported synthesis, poly(ethyleneglycol), amino acid.

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