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Eur. J. Mass Spectrom. 4, 265 - 268 (1998) |
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Fast-atom bombardment mass spectrometry of netilmicin and its 6'-N-aminoacyl derivatives | ||
S.I. Kotretsou and V. Constantinou-Kokotou* |
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ABSTRACT: | ||
Mass spectrometric studies on the fragmentation of the clinically used antibiotic netilmicin and its 6'-N-aminoacyl derivatives are reported. Glycosyl cleavage at the C-4 and C-6 positions of the 2-deoxystreptamine unit (2-DOS) forms the main ions. | ||
Keywords: Netilmicin, 6'-N aminoacyl derivatives, FAB, aminocyclitol antibiotics, aminoglycosides. |
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