Letter: Fast atom bombardment, electrospray, ionspray and tandem mass spectrometry of 1 : 1

b-cyclodextrin/5-methoxytryptamine hydrochloride hostguest complex: host protonation and fragmentation due to guest deamination

Full-text article (56 kB)
(subscribers only)

Buy article on-line for £11.75
(get immediate access)

Search

Go Back

Eur. J. Mass Spectrom. 6, 169 - 174 (2000)

Letter: Fast atom bombardment, electrospray, ionspray and tandem mass spectrometry of 1 : 1 b-cyclodextrin/5-methoxytryptamine hydrochloride hostguest complex: host protonation and fragmentation due to guest deamination

Andrea Mele, Walter Panzeri and Antonio Selva^*
C.N.R.- Centro di Studio sulle Sostanze Organiche Naturali, Dipartimento di Chimica del Politecnico di Milano, Via Mancinelli, 7, I-20131 Milano, Italy
Pierluigi Mauri
C.N.R.-Istituto Tecnologie Biomediche Avanzate, I-20090 Segrate, Italy

ABSTRACT:

The 1 : 1 inclusion complex of b-cyclodextrin (bCD) with 5-methoxytryptamine (5MTA) hydrochloride was studied by mass spectrometry (MS) and tandem-MS with fast atom bombardment (FAB), electrospray (ES) and ionspray (IS) ionisation and triple quadrupole or ion trap analysers. A protonated 1 : 1 bCD/MTA gaseous association was always observed; the protonated species of deaminated 5MTA and of some typical bCD fragments were obtained, in addition to the expected protonated 5MTA, as tandem-MS dissociation products. A reaction pattern starting from the deamination of protonated 5MTA, as a recently described high pressure chemical ionisation or ES process of primary amines, was suggested, which accounts for the formation of excited protonated bCD and its fragmentation by tandem-MS, even under unimolecular conditions.

Keywords: b-cyclodextrin, hostguest complexes, 5-methoxytryptamine, FAB, electrospray/ionspray, tandem mass spectrometry

You can now buy this paper on-line in PDF format; it costs only £11.75. Just click on the BUY on-line button. You can pay on-line through a secure server and get access immediately.