A 9.4 T Fourier transform ion cyclotron resonance mass spectrometer: description and performance

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Eur. J. Mass Spectrom. 6, 267 - 275 (2000)

A 9.4 T Fourier transform ion cyclotron resonance mass spectrometer: description and performance

Magnus Palmblad, Kristina Håkansson and Per Håkansson
Division of Ion Physics, The Ångström Laboratory, Uppsala University, Box 534, SE-751 21 Uppsala, Sweden
Xidong Feng, Helen J. Cooper, Anastassios E. Giannakopulos, Philip S. Green and Peter J. Derrick^*
Institute of Mass Spectrometry and Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK

ABSTRACT:

9.4 Tesla Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometers (Bruker BioAPEX-94e) have been installed at the Division of Ion Physics, Uppsala University, and at the Department of Chemistry, University of Warwick. The BioAPEX-94e FT-ICR instrument is built around a high-field, superconducting magnet and a platform with easily interchangeable ion sources [matrix-assisted laser desorption/ionisation (MALDI), secondary ion mass spectrometry (SIMS), electrospray ionisation (ESI) and electron impact/chemical ionisation (EI/CI)]. In this paper a technical description of the instrument is given. Outstanding performance characteristics are demonstrated, notably clear resolution of C₅₉N⁺ and C₅₈¹³C²⁺ (mass difference 3.65 mDa) and mass measurement accuracy at the low ppm level. A wide range of applications in Warwick and Uppsala is described, demonstrating the versatility and high performance of the instrument.

Keywords: FT-ICR, ESI, nanospray, MALDI, SIMS, EI/CI, sustained off-resonance irradiation / collision-induced dissociation (SORI/CID), electron capture dissociation (ECD), multipole-storage assisted dissociation (MSAD), quadrupolar excitation axialisation (QEA), infrared multiphoton dissociation (IRMPD)

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