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Eur. J. Mass Spectrom. 8, 79 - 84 (2002) |
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Polymer track membranes for extraction of ions from aqueous solutions at atmospheric pressure | ||
Alexander. A. Balakin,* Alexander F. Dodonov, Mikhail I. Markin, Lyudmila I. Novikova, Ilia V. Soulimenkov and Victor L. Talroze< |
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ABSTRACT: | ||
The possibility of the application of the electromembrane technique for production of ions of biological molecules at atmospheric pressure is demonstrated. This technique has previously only been used for extraction of ions from liquids directly into vacuum. The membrane technique for ion extraction at atmospheric pressure was tested with both time-of-flight and Fourier transform ion cyclotron resonance mass spectrometers. The mass spectra of intact molecular ions obtained from aqueous solutions of peptides and proteins are presented. The possible mechanisms of non-destructive ion extraction are discussed. The new technique is promising for achieving absolute sensitivity (charging every analyte molecule) and for performing spatially-resolved analysis of liquid biological samples. | ||
Keywords: ion extraction from solutions, track membranes, mass spectrometric analysis of polypeptides |
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