Letter: Complexes of amino (6-monodeoxy-6-mono)-b-cyclodextrin probed by electrospray ionization mass spectrometry

Eur. J. Mass Spectrom. 5, 1–5 (1999)
DOI: 10.1255/ejms.242

Letter: Complexes of amino (6-monodeoxy-6-mono)-b-cyclodextrin probed by electrospray ionization mass spectrometry

Ray Bakhtiar
Department of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, NJ 07030, USA.

ABSTRACT:

The first examples of molecular complexes of a substituted b-cyclodextrin, amino (6-monodeoxy-6-mono)-b-cyclodextrin (b-CDNH₂), with several drugs and amino acids are examined using electrospray ionization mass spectrometry. The analysis of samples which contained b-CDNH₂ with cis-2-(4-methoxyphenyl)-3,4-dimethyl 5-phenyloxazolidine (an oxazolidine prodrug of (1R,2S)-(–)-ephedrine), dacarbazine, ibuprofen, terbutaline, fenoterol, amphetamine, methylphenidate, glyburide, tyrosine, tryptophan or phenylalanine are discussed. Control experiments and observation of &#147false positives” are also presented.

Keywords: Cyclodextrin, electrospray, non-covalent, false-positive, inclusion.

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