Prion (PrPres) allotypes profiling: a new perspectives from mass spectrometry

Eur. J. Mass Spectrom. 10, 371–382 (2004)
DOI: 10.1255/ejms.602

Prion (PrPres) allotypes profiling: a new perspectives from mass spectrometry

Bruno Maras, Donatella Barra and M. Eugenia Schininà^*
Dipartimento of Scienze Biochimiche ”A. Rossi Fanelli”, Università La Sapienza, Piazzale Aldo Moro, 5, 00185 Rome, Italy
Franco Cardone and Maurizio Pocchiari
Dipartimento di Biologia Cellulare e Neuroscienze, Istituto Superiore di Sanità, Rome, Italy.

ABSTRACT:

Biochemical methods employed for PrPres allotypes profiling are reviewed and compared with the latest mass spectrometric approaches. Emphasis is put on the advantages offered by a recently proposed electrospray strategy.

Keywords: Mass spectrometry, transmissible spongiform encephalopathies, prion protein, allotype profiling

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