Characterization of a novel trace-level impurity in lisinopril using multi-stage mass spectrometry

Eur. J. Mass Spectrom. 12, 121–127 (2006)
DOI: 10.1255/ejms.801

Characterization of a novel trace-level impurity in lisinopril using multi-stage mass spectrometry

Saifeng Pei, Danhua Wang, Cuirong Sun^* and Yuanjiang Pan
Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang Province 310027, China

ABSTRACT:

An impurity in the bulk drug lisinopril was detected by simple reversed-phase high-performance liquid chromatography (HPLC). This trace-level impurity was rapidly identified as 2-(2-oxo-azocan-3-ylamino)-4- phenyl-butyric acid on the basis of the on-line multi-stage mass spectrometric evidence, and the proposed structure was further confirmed by multi-stage mass spectrometry (MSⁿ) of lisinopril and three related compounds.

Keywords: lisinopril, impurity, characterization, HPLC, MSⁿ

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