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by Ronald E. Reid (Ed.)
Furthering efforts to simulate the potency and specificity exhibited by peptides and proteins in healthy cells, this remarkable reference supplies pharmaceutical scientists with a wealth of techniques for tapping the enormous therapeutic potential of these molecules—providing a solid basis of knowledge for new drug design.
Provides a broad, comprehensive overview of peptides and proteins as mediators of cell movement, proliferation, differentiation, and communication.
Written by more than 50 leading international authorities, Peptides and Protein Drug Analysis
* discusses strategies for dealing with the complexity of peptides and proteins in conformational flexibility and amino acid sequence variability
* analyzes drug formulations facilitated by solid-phase peptide synthesis and recombinant DNA technology
* examines chemical purity analysis by high-pressure chromatographic, capillary electrophoretic, gel electrophoretic, and isoelectric focusing methods
* highlights drug design elements derived from protein folding, bioinformatics, and computational chemistry
* demonstrates uses of unnatural mutagenesis and combinatorial chemistry
* explores mass spectrometry, protein sequence, and carbohydrate analysis
* illustrates bioassays and other new functional analysis methods
* surveys spectroscopic techniques such as ultraviolet, fluorescence, Fourier transform infrared, and nuclear magnetic resonance (NMR)
* addresses ways of distinguishing between levels of therapeutic and endogenous agents in cells
* reviews structural analysis tools such as ultracentrifugation and light, X-ray, and neutron scattering
* and more!
Featuring over 3400 bibliographic citations and more than 500 tables, equations, and illustrations, Peptide and Protein Drug Analysis is a must-read resource for pharmacists; pharmacologists; analytical, organic, and pharmaceutical chemists; cell and molecular biologists; biochemists; and upper-level undergraduate and graduate students in these disciplines.
Hardback
Pages: 904
Published: 1999
Contents
STRATEGIES
Practical Principles of Protein Design,
Ronald E. Reid and Patrick L. Franchini
Peptidomimetic and Nonpeptide Drug Discovery: Concepts, Strategies, and Technologies,
Tomi K. Sawyer
Structure Prediction and Molecular Modeling,
Robin E. J. Munro and William R. Taylor
Chemical Synthesis of Peptides,
Henriette A. Remmer and Gregg B. Fields
Chemical Synthesis of Proteins,
Graham J. Cotton, Maria C. Pietanza, and Tom W. Muir
Introduction of Unnatural Amino Acids into Proteins,
Scott A. Lesley
Combinatorial Chemistry and the Structure-Function Analysis of Proteins,
Rachel L. Winston and Michael C. Fitzgerald
Folding Polypeptides for Drug Production and Discovery,
Elizabeth Strickland, Philip J. Thomas, and Ming Li
Protein and Peptide Chemical and Physical Stability,
Bernard N. Violand and Ned R. Siegel
Bioinformatics and Computational Chemistry in Molecular Design: Recent Advances and Their Applications,
Jin Li and Barry Robson
CHEMICAL ANALYSIS
High Pressure Liquid Chromatography of Peptides and Proteins,
Marie-Isabel Aguilar
Practical Aspects of Peptide and Protein Analysis by Capillary Electrophoresis,
Nicole J. Munro, Andreas Hühmer, and James P. Lander
Gel Electrophoresis of Peptides and Proteins,
Michael J. Dunn
Carbohydrate Analysis of Glycoproteins and Glycopeptides,
Nigel Jenkins, Pir M. Shah, and Lorraine D. Buckberry
Protein Sequence Analysis
Hsieng S. Lu, Lee Anne Merewether, and Michael F. Rohde
Mass Spectrometry,
Vic Garner
FUNCTIONAL ANALYSIS
Protein and Peptide Immunoassays,
Anthony B. Chen
Pharmacogenomics,
Ann K. Daly and Jane Grove
Analysis of Polypeptide Bioactivity,
David C. Wood, Q. Khai Huynh, and Joseph B. Monahan
Pharmacokinetics and Pharmacodynamics of Protein Therapeutics,
Rene Braeckman
Approaches to Validating the Identity of Peptides and Proteins,
Ian R. Tebbett and Nancy D. Denslow
STRUCTURAL ANALYSIS
Solution Structure Determination of Proteins by Nuclear Magnetic Resonance Spectroscopy,
Nicholas J. Skelton and Walter J. Chazin
NMR Studies of Protein-Peptide Complexes: Examples from the Calmodulin System,
A. Joshua Wand, Jeffrey L. Urbauer, Mark R. Ehrhardt, and Andrew L. Lee
Circular Dichroism and Fourier Transform Infrared Analysis of Polypeptide Conformation,
Graeme J. Anderson
Electron Paramagnetic Resonance of Peptides and Proteins,
Derek Marsh
UV-Visible and Fluorescence Spectroscopy of Polypeptides and Proteins,
G. M. Anantharamaiah, Vinod K. Mishra, Geeta Datta, and Herbert C. Cheung
Ultracentrifugation, Light-, X-ray-, and Neutron-Scattering of Peptides, Proteins and Nucleic Acids in Solution,
Henryk Eisenberg
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