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by W. Niessen
This extensively updated reference provides a comprehensive account of the latest developments, principles, and applications of combined liquid chromatography-mass spectrometry (LC-MS) and related techniques. Liquid Chromatography-Mass Spectrometry, Second Edition
* offers more in-depth and comprehensive coverage of all interfaces and technologies currently important in the laboratory, especially electrospray and APCI
* contains an expanded applications section spanning five complete chapters—four more than in the first edition
* features more extensive discussions on the optimization of experimental conditions and ionization techniques for all important LC-MS interfaces
* gives a historical overview describing all approaches to online LC-MS
* includes a comprehensive discussion of interfacing and applications of supercritical fluid chromatography—mass spectrometry and capillary zone electrophoresis-mass spectrometry
* and more!
With over 2200 references, tables, equations, and drawings, Liquid Chromatography-Mass Spectrometry, Second Edition is suitable for analytical chemists; chromatographers and mass spectrometrists; operators, researchers, and research managers involved in LC-MS; environmental and biopharmaceutical chemists, biochemists, and biotechnologists; and in-house training courses and professional seminars on LC-MS or analytical mass spectrometry.
Hardback
Pages: 648
Published: 1998
Contents
GENERAL INTRODUCTION
Introduction to Liquid Chromatography
Introduction to Mass Spectrometry
General Instrumental Considerations in LC-MS Interfacing
INTERFACE TECHNOLOGY
History of LC-MS
Particle-Beam Interface
Continuous-Flow Fast-Atom Bombardment
Thermospray Interface
Nebulization Ionization in LC-MS
Electrospray Interfacing
Atmospheric-Pressure Chemical Ionization Interfaces
Recent Developments in LC-MS Interfacing
APPLICATIONS
Environmental Applications of LC-MS
Pharmaceutical Applications of LC-MS
Natural Products and Endogenous Compounds
Biochemical Applications of LC-MS
Miscellaneous Applications of LC-MS
RELATED TECHNIQUES
Supercritical Fluid Chromatography Mass Spectrometry
Capillary Electrophoresis Mass Spectrometry
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