by Birendra N. Pramanik, A.K. Ganguly and Michael L. Gross

Discusses current strategies to determine the structure and machanisms of numerous compound classics. Covers new chemical and elctrophoretic techniques for rapid sample preconcentration and separation.

This state-of-the-art reference/text summarizes the most recent breakthroughs in the theory and instrumentation of electrospray mass spectrometry in pharmaceutical and biomedical applications—providing practical examples for the characterization of peptides, proteins, and glycoproteins, as well as applications in proteomics, combinatorial chemistry, and drug characterization.

Discusses current strategies to determine the structure and mechanisms of numerous compound classes, including synthetic organic compounds, β-lactams, steroids, macrocyclic compounds, peptides, glycoproteins, oligosaccharides, proteins, lipids, and polymers!

Detailing the latest advances in proteomics, noncovalent complexes of ligands and proteins, nanoflow methods, and combinatorial chemistry, Applied Electrospray Mass Spectrometry covers

* new chemical and electrophoretic techniques for rapid sample preconcentration and separation

* modern screening processes for proteins from libraries of compounds

* sensitive ionization methods for large biomolecules

* the profiling of metabolites in in vivo and in vitro matrices

* protein folding and dynamics

With more than 1000 contemporary references, Applied Electrospray Mass Spectrometry is an invaluable reference for mass spectrometrists; analytical, medicinal, and protein chemists and biochemists; biotechnologists; enzymologists; molecular biologists; and pharmaceutical scientists; and an excellent text for upper-level undergraduate and graduate students in these disciplines.

Hardback
Pages: 464
Published: 2002