by David T. Rossi and Michael W. Sinz (Eds)

This state-of-the-art reference summarises the theory, instrumentation, and application of mass spectrometry and atmospheric pressure ionization to screen, evaluate, and improve the performance and quality of drug candidates—offering current techniques in pharmaceutics and pharmacokinetics for increased quantities of new pharmaceutical compounds.

Providing time- and cost-efficient approaches for the generation and analysis of effective pharmaceuticals, Mass Spectrometry in Drug Discovery covers:

* recent advances in combinatorial chemistry, molecular biology, bioanalysis automation, and computing

* cassette dosing in drug discovery

* the utilization of liquid chromatography/mass spectrometry (LC/MS) in chemical library characterization, combinatorial chemistry, drug transport, and in vivo microdialysis

* reliable methods of sample preparation and handling

* novel strategies to determine and characterize metabolite structures

* the impact of absorption, distribution, metabolism, and elimination properties on drug discovery

* the latest research using stable-labeled compounds

Demonstrating the use of mass spectrometry in the assessment of disease states, drug targets, and potential drug agents, Mass Spectrometry in Drug Discovery is an invaluable source for spectrometrists; pharmacologists; analytical, medicinal, and organic chemists and biochemists; biotechnologists; pharmaceutical scientists; toxicologists; and upper-level undergraduate and graduate students in these disciplines.

Hardback
Pages: 432
Published: 2001